RESEARCH INTERESTS

The laboratory is a part of the Cellular and Molecular Arrhythmia Research Program (CMARP) and Cardiovascular Research Center (CVRC) involving multiple investigators working on a wide range of research projects exploring the molecular function of ion channels in human physiology, pharmacology, and disease. The primary goal of our research is to improve the health of people with cardiac arrhythmias, including the most common abnormal heart rhythm, atrial fibrillation, affecting about 2% to 3% of the Western population. To accomplish this, we aim to identify novel diagnostic tools and therapeutic targets through investigation of cellular and molecular mechanisms of cardiac remodeling and arrhythmogenesis. Our group has a multidisciplinary background that includes expertise in physiology, cell biology, biomedical engineering, biophysics, and confocal microscopy. This unique set of skills allows us to investigate mechanisms of arrhythmias across multiple scales from protein expression, localization and function, to electrical and mechanical activity of an intact heart. Our research is specifically focused on elucidating the functionality of subcellular nanodomains and their role in regulation of proteins responsible for normal and pathophysiological electro-mechanical activity of the heart. We pursue two main directions: (1) determining the cellular and molecular mechanisms underlying normal electrical activity and dysfunction of the sinoatrial node, the heart’s natural pacemaker, and (2) discovering novel strategies for atrial fibrillation treatment and risk stratification.

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Lab News

February 21, 2022
Congratulations Di!

Dr. Di Lang received a promotion to a position of Assistant Adjunct Professor at University of California at San Franciscostarting in July 2022. Way to go Di!

February 16, 2022
Planning Heart Rhythm 2022!

Daniel Turner’s abstract on iPSC-CM based atrial-like engineered cardiac tissue constructs was accepted for a poster presentation at Heart Rhythm 2022 in San Francisco, April 29-May 1, 2022. Congrats Dan!

December 24, 2021
American Journal of Physiology paper now online!

Our paper on atrial transversal-axial tubules and calcium signaling is now available online. Good job, Di and Roman!