Alexey Glukhov, Ph.D.

Principal Investigator

  aglukhov@medicine.wisc.edu

 

I am Assistant Professor at Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison. My laboratory is a part of the Cellular and Molecular Arrhythmia Research Program (CMARP) involving multiple investigators working on a wide range of research projects exploring the molecular function of ion channels in human physiology, pharmacology and disease. I have a broad multidisciplinary background that combines my expertise in physiology, cell biology, biomedical engineering, biophysics, and confocal microscopy. I have an active, NIH- and AHA-funded, basic research laboratory focused on cardiovascular research which combines several state-of-the-art techniques, including high-resolution fluorescent optical mapping and scanning ion conductance microscopy equipped with super-resolution scanning patch-clamp. These are applied to investigate mechanisms involved in atrial, sinoatrial node, and ventricular cardiac remodeling and arrhythmogenesis following hypertension, heart failure, and atrial fibrillation among multiple levels of cardiac signaling: from protein expression, phosphorylation, and sub-cellular localization, protein-protein interaction, to propagation and repolarization of an intact heart. I am particularly interested in understanding the functionality of distinct subcellular microdomains in cardiac myocytes, such as transversal (t)-tubules, caveolae, and various costamers, and their functional role in the accumulation, neuro-hormonal and mechanical regulation of proteins responsible for normal and pathophysiological electrical activity and contraction of the heart, and how microdomain-targeted remodeling of those proteins contributes to abnormal cardiac electrophysiology and arrhythmogenesis associated with various pathologies.

Experience and Qualifications as Mentor: Since my faculty appointment at UW-Madison in 2015, I have mentored seven postdoctoral fellows, three graduate students, and twenty-five undergraduate students. Of those 35 trainees, 14 are women, and 2 are from groups that are traditionally underrepresented in science. I am committed to not only supporting and mentoring a diverse group of scientists, but also fostering an environment and climate within my group that is inclusive and supportive to all.

My trainees received multiple recognitions, including eight poster competition winning prizes, two Hilldale-Holstrom Undergraduate Student Fellowships, one undergraduate, one predoctoral and two postdoctoral AHA fellowships, one Goldwater Undergraduate Student Scholarship, one UW-Madison Cardiovascular Research Center Undergraduate Student Scholarship, two travel awards from the Biophysical Society, two AHA Career Development Awards, individual grants from UW-Madison Department of Medicine Research Committee, UW-Madison Institute of Translational and Clinical Research, and UW-Madison graduate programs.

I am a trainer on UW-Madison Cardiovascular Research Center NIH T32 program, Molecular and Cellular Pharmacology NIH T32 program, Cellular and Molecular Biology Graduate Program, UW Stem Cell and Regenerative Medicine Center Training Program, and on an AHA Predoctoral and Postdoctoral Research Fellowships, and serve on Molecular and Cellular Pharmacology NIH T32 Program Recruiting Committee from 2018.

Education and Training:

2012-2015 Postdoctoral training in Biophysics, Heart Science section at the National Heart & Lung Institute, Imperial College London, United Kingdom

2011-2012 Postdoctoral training in physiology, the Ohio State University, Columbus, USA

2007-2010 Postdoctoral training Biomedical Engineering, Washington University in St. Louis, USA

2007 Ph.D. in Biology, Specialty in Physiology, Institute of Theoretical and Experimental Biophysics of Russian Academy of Science and Cardiology Research Centre, Moscow, Russia

2003 M.Ss. in Biophysics, Moscow Institute of Physics and Technology, Russia

2001 B.S. in Biophysics, Moscow Institute of Physics and Technology, Russia

Publications (selected):

Complete list of publications (GoogleScholar)

Lab publications (from UW-Madison)

Grants:

  • NIH/NHLBI R01 HL41214 (2018-2023), Glukhov (PI), “Functional Microdomains in the Heart’s Pacemaker: A New Dimension of Cardiac Remodeling”
  • NIH/NHLBI 1R01HL139738-01A1 (2018-2022), Eckhardt (PI, Glukhov (Co-I), “KCNJ2 Mutation-Induced Arrhythmia Mechanisms in CPVT Phenotypes”
  • NIH/NHLBI 1R01HL146652-01A1 (2020-2023), Zhao (PI), Glukhov (Co-I), “Engineered anisotropic and vascularized human cardiac patch”
  • Office of the Vice Chancellor for Research and Graduate Education (OVCRGE)/Wisconsin Alumni Research Foundation (WARF) Fall Competition Award (2021-2022), Glukhov (PI), “Atrial-like Engineered Cardiac Tissue as a Novel Model for Cardiac Pressure Overload and Atrial Fibrillation Pathogenesis”