Daniel Turner, B.Sc.
Dan Turner is a research trainee and American Heart Association (AHA) predoctoral fellow pursuing a PhD with the Molecular and Cellular Pharmacology (MCP) Training Program in Dr. Alexey Glukhov’s lab. Previously, Dan performed research on Rett Syndrome with the Dr. Qiang Chang Lab and was employed as an analytical research chemist at The Center for Dairy Research (CDR) at UW-Madison. In the Glukhov lab, Dan is the designated molecular biologist with technical experience in optimizing protocols related to human cell culture and evaluation of protein and gene expression for various cell types. His current research interests revolve around cardiac mechanosensitivity and its effect on cardiac performance in the healthy heart and during disease. Specifically, he has founded new research avenues implementing engineered cardiac tissue (collaboration with Dr. John Carter Ralphe) to study mechano-chemical signal transduction of the heart, its possible effect on caveolae expression, and subsequent effects on overall cardiac function that may underlie mechano-electrical effects that give rise to atrial fibrillation and other hypertension-induced cardiac diseases. Broadly speaking, Dan’s research is focused on cardio-protective cardiomyocyte membrane structures, namely caveolae, which are implicated in mechanotransduction by buffering mechanical forces and regulating various ion channels and signaling proteins.
2019 Molecular and Cellular Pharmacology (MCP) Graduate Program Symposium – Poster Finalist
2019 UW-Madison Cardiovascular Research Center (CRVC) 25th Annual Research Summit – Poster Finalist
2020 MCP NIH T32 Trainee Research Project Grant – Recipient
2021 Office of the Vice Chancellor for Research and Graduate Education (VCRGE) Fall Research Competition, Graduate Student Grant – Recipient
2021 American Heart Association Predoctoral Fellowship – Recipient
2021 MCP NIH T32 Travel Award attend Heart Rhythm/Cardiac Electrophysiology Society Meeting – Recipient
- Turner D, Tyan L, DeGuire FC, Medvedev RY, Stroebel SJ, Lang D, Glukhov AV. Caveolin-3 Prevents Swelling-Induced Membrane Damage via Regulation of ICl,swell Activity. Resubmitted to Biophysical Journal. 2022.
- Turner D, Kang C, Mesirca P, Hong J, Mangoni ME, Glukhov AV, Sah R. Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity. Front Cardiovasc Med. 2021; 8:662410.
- Turner D, Tyan L, Stroebel S, DeGuire FC, Lang D, Glukhov AV. Caveolin-3 Prevents Swelling-Induced Cell Lysis via Regulation of ICl,swell Activity. Presented at BCVS Scientific Sessions 2021. Circulation Research 129 (Suppl_1), AP368-AP368.
- Tyan L, Turner D, Komp KR, Medvedev R, Lim E, Glukhov AV. Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes. Am J Physiol Heart Circ Physiol. 2021; 320(2): H787-H797.
- Turner DG, Tyan L, Stroebel S, DeGuire F, Lang D, Glukhov AV. Caveolin-3 enriches and dynamically interacts with SWELL1. Presented at BCVS Scientific Sessions 2020. Circulation Research 127 (Suppl_1), A423-A423.
- Lang D, Tyan L, Turner D, Alvarado FJ, Piro ZD, Medvedev R, Warden A, Lim E, Lodin R, Irwin A, Valdivia HH, Kamp TJ, Glukhov AV. Caveolar Disruption Of L-type Calcium Channel and Ryanodine Receptor Facilitates Atrial Ectopy and Arrhythmogenesis In Heart Failure Mice. Presented at BCVS Scientific Sessions 2020. Circulation Research 127 (Suppl_1), A418-A418.
- Egorov YV, Lang D, Tyan L, Turner D, Lim E, Piro ZD, Hernandez JJ, Lodin R, Wang R, Schmuck EG, Raval AN, Ralphe CJ, Kamp TJ, Rosenshtraukh LV, Glukhov AV. Caveolae-Mediated Activation of Mechanosensitive Chloride Channels Triggers Atrial Arrhythmogenesis. J Am Heart Assoc. 2019; 8(20): e012748.
- Bu Q, Wang A, Hamzah H, Waldman A, Jiang K, Dong Q, Li R, Kim J, Turner D, Chang Q. CREB Signaling Is Involved in Rett Syndrome Pathogenesis. J Neurosci. 2017; 37(13):3671-3685.