Di Lang, Ph.D.

Scientist III

  dlang@medicine.wisc.edu

 

I am a Scientist (III) working at the Cellular and Molecular Arrhythmia Research Program (CMARP) within the Department of Medicine, University of Wisconsin-Madison. My research interest focuses on understanding the sino-atrial node and atrial physiology and pathology through the association of structural remodeling, distinct regulatory and functional disruptions. During over ten years investigating the mechanisms and future therapeutics for cardiac arrhythmia, I have developed and applied multimodal imaging techniques in the studies using distinct heart disease animal models including murine, rabbit, canine, and especially human hearts as well as human induced pluripotent stem cells (hiPSC). My work has so far led to 28 peer-review publications, 2 book chapters. I have continuously led 4 granted projects as the principal investigator since 2016.

Education:

2005 B.S. in Biomedical Engineering, Zhejiang University, Hangzhou, China

2008 M.Sc. in Biomedical Engineering, Zhejiang University, Hangzhou, China

2013 Ph.D. in Biomedical Engineering, Washington University in St. Louis, St. Louis, MO

2013 – 2015 Postdoctoral training in pharmacology, University of California Davis, Davis, CA

2015-2018 Postdoctoral training on physiology and stem cell biology, University of Wisconsin Madison, Madison, WI

Honors, Awards and other Professional Activities:

2021 American Heart Association (AHA) Career Development Award, Recipient

2020 64th Biophysical Society Conference Undergraduate Poster Section Leading Judge

2020 Editor Board, Review Editor, Frontiers in Physiology

2019 Biophysical Society Travel Award

2019 Cardiovascular Research Summit Best Poster Award

2018 University of Wisconsin Madison Pilot Grant Award

2018 14th Annual Signal Transduction Research Symposium Best Poster Award

2017 American Heart Association Postdoctoral Fellowship Award

2017 Associated Guest Editor, Topic Editor, Frontiers in Physiology (Cardiac Electrophysiology)

2017 Gordon Conference Travel Award: Cardiac Arrhythmia Mechanisms

2016 American Heart Association Travel Grant Award

2016 22nd Scientific Poster Fair Award of University of Wisconsin Madison

2015 Research Day Best Poster Winner of University of Wisconsin Madison

2014 Consulting Editor, Research Reports in Clinical Cardiology

2013 Consulting Editor, Medical Devices: Evidence and Research

Member:

American Heart Association; Heart Rhythm Society; Biophysics society

Selected publications:

Complete list of publications (GoogleScholar)

Grants:

  • American Heart Association (AHA) Career Development Award (2021-2024), Lang (PI.

Title: “Supraventricular Arrhythmogenesis associated with CPVT-linked RyR mutations”

  • Institute of Translational and Clinical Research Grant Award (2020-2021); Lang (PI).

Title: “Novel precision therapeutic strategies for catecholaminergic polymorphic ventricular tachycardia using human induced pluripotent stem cells”.

  • NIH/NHLBI 1R01HL141214-01 (2018-2023), Glukhov (PI), Lang (Co-I).

Title: “Functional microdomains in the heart’s pacemaker: a new dimension of cardiac remodeling”.

  • NIH/NHLBI 1R01HL139738-01 A1 (2018-2022), Eckhardt (PI) Lang (Co-I).

Title: “KCNJ2 Mutation-Induced Arrhythmia Mechanisms in CPVT Phenotypes”.

  • Pilot Grant University of Wisconsin Madison (201802019), Lang (PI).

Title: “Supraventricular arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia”

  • American Heart Association (AHA) 17POST33370089 (2016-2018), Lang (PI)

Title: “The role of caveolin-3 in the mouse sinoatrial node functioning and atrial arrhythmogenesis”