Roman Medvedev, Ph.D.

  rmedvedev@wisc.edu

 

I have started my carrier as a chemist. My first project in the Prof. E.F. Panarin laboratory at St Petersburg State University (Russia) was devoted to investigate new biocompatitive sorbents for glucose hemosorption. I have synthesized a new sorbent with a high potency in selective glucose sorption. This study was published in Russian Journal of Organic Chemistry in 2017. This work has drawn my attention to biology and for my master course I moved to electrophysiology and biophysics field. I have joined laboratory leaded by Dr. O.S. Ostroumova at St Petersburg State University (Russia) where I studied electrophysiology of ion channels incorporated in artificial lipid biomembranes. I focused my research on membrane-mediated effects of various clinically relevant substances. During this time, I have established a new mechanism of local anesthetic effect that works through lipid membrane liquefaction. This study was published in the Russian Cell and Tissue Biology journal in 2017. Another important finding of my master work was the understanding of lipid-mediated action of polyphenols on several ion channels. This membrane-associated effect is crucial for drag safety studies. The work was subsequently published at the Journal of Membrane Biology in 2018. Working in Dr. Ostroumova laboratory gained my technical expertise in electrophysiology and general laboratory skills.
My PhD training lied on collaboration between University of Verona (Italy) and Imperial College London (UK). The project was devoted to investigate the microdomain organization of excitation-contraction coupling in healthy right and left ventricular myocytes. I identified major differences in structural membrane organization and calcium signaling between right and left ventricular myocytes and presented these findings at the European Society of Heart Research in 2018. These baseline differences between the right and left ventricle excitation-contraction coupling were incorporated in the bigger project directed to study right ventricular remodeling in the settings of pulmonary arterial hypertension and heart failure. The results of my studies were published in the Hypertension and Scientific Reports journals in 2020. During this time, I improved my technical skills, learned more about cardiac electrophysiology and significantly improved my communication skills.
My current research at the laboratory of Dr. Alexey Glukhov is based on my experience in cardiac calcium signaling in ventricular myocytes and extends in stretch-induced atrial arrhythmogenesis. As compared to ventricular myocytes, atrial cells have more heterogeneous population and broader spectrum of characteristics. When I joined the Glukhov lab, I was interested in investigation the correlation between membrane structural organization and functional properties, including calcium signaling and contraction. My preliminary studies presented at BCVS 2020 and AHA 2020 meetings showed a region-specific distribution transversal-axial tubule system (TATS) in mouse and human atria that critically impact regional heterogeneity of Ca2+ signaling and may underlie the formation of arrhythmogenic ectopic foci under pathological conditions. This work was published at Am J Physiol Heart Circ Physiol in 2022. During postdoctoral training I was also involved in other projects from Glukhov laboratory including (1) the investigation the compartmentation of angiotensin II receptors in atrial myocytes via caveolin-3 (published in Am J Physiol Heart Circ Physiol, 2021), (2) understanding the structural basis of coordinated voltage and calcium clocks in cardiac pacemaker cells (under major revision for Circulation Research) and (3) studying the modulatory role of caveolin-3 on mechanosensitive chloride channels (major revision for Biophysical Journal). For all these projects, I applied my expertise in microdomain-specific organization of cardiomyocyte signalosomes and the role of caveolar scaffolding proteins in cardiac physiology and arrhythmogenesis. The results of these studies leaded me to develop the current project focused on the role of caveolin-3 in mechano-chemical signal transduction in healthy and diseased atrial myocytes.

Positions and Employment

2013 – 2014 Research assistant, Institute of Macromolecular Compounds RAS, Saint-Petersburg, Russia

2014 – 2016 Research assistant, Institute of Cytology RAS, Saint-Petersburg, Russia

2016 – 2019 Frequent researcher, Humanitas Research Center, Rozzano, Italy

2017 – 2018 Visiting student, Imperial College, London, UK

2019 – 2019 Visiting student, University of Parma, Italy

2019 – 2020 Research intern, University of Wisconsin Madison, WI, USA

2020 – now Research Associate, University of Wisconsin Madison, WI, USA

Other Experience and Professional Memberships

2020 – now Member, American Heart Association

Honors:

2017 University of Verona travel grant for exchange with Imperial college London, University of Verona, Italy

2018 University of Verona travel grant for exchange with Imperial college London, University of Verona, Italy

2020 2nd place poster price CVRC Postdoctoral Poster Fair at University of Wisconsin-Madison

2021 American Heart Association (AHA) Postdoctoral Fellowship, Recipient

Publications: